database migration sql express to sql 2008 R2

good afternoon,
I have installed backup exec 2012 on which works with a sql database express, the problem is that you quickly fill your data that exceeds 4 GB,
the need I have is to make the migration of database sql express database to sql 2008 R2 since it has licensed.
my question is there will be a process of good practice for such migration

thank you for your help thanks.