Cannot backup directory \zzzVirtApp000zzz and its subdirectories

Hello

I'm having an issue with GRT backups of our Exchange 2010 SP1 Virtual Machine. Whenever I run a GRT enabled backup of this VM, it fails with the following errors. I'm not sure if it's a problem with the Volume above the error or with something else. 

Exchange is installed on Windows 2008 R2 on a VMware ESX 4.1 VM and I'm backing it up with Backup Exec 2010 R3 SP3. There's plenty of free space on all drives as well. Searching that Volume and I believe it points to the System Reserved partition of the C Drive. Any ideas as to what I can try to fix this?

Thank you!

Backup Exec has discovered and protected 'C:' on virtual machine '\\ExchangeServer'.
Backup Exec has discovered and protected 'D:' on virtual machine '\\ExchangeServer'.
Backup Exec has discovered and protected 'Volume{0dc6eb8c-941a-11df-b8e0-806e6f6e6963}' on virtual machine '\\ExchangeServer'.
V-79-57344-65247 - Error. Cannot backup directory \zzzVirtApp000zzz and its subdirectories.
Backup Exec has discovered and protected Microsoft Exchange Server data on virtual machine '\\ExchangeServer'.
Backup Exec has discovered and protected Microsoft Exchange Server data on virtual machine '\\ExchangeServe

Completed status: Failed
Final error: 0xe000fedf - A failure occurred reading an object.
Final error category: Resource Errors