Error : e00084af - The directory or file was not found, or could not be accessed.

Running Backup Exec 2010 R3 13.0 Rev 5204 32 bit.  We backup file server to a backup server with a disk array using a dedicated network connection between the systems. Started receiving  this error:

Error             : e00084af - The directory or file was not found, or could not be accessed.

The junction point item was set to no with no impact.  A backup can die because of the error 5 minutes into the backup or 13 hours into the backup.  ANy thoughts or suggestions?